altered.wiki - User contributions [en]

Wiki/Clonahydroxyethylencepam

2026-05-25T16:11:26Z

Skali: Added image, will add info later

[[File:Chemical structure of Clonahydroxyethylencepam.svg|thumb]]

File:Chemical structure of Clonahydroxyethylencepam.svg

2026-05-25T16:11:16Z

Skali:

Chemical structure of Clonahydroxyethylencepam

Wiki/How to make a good wiki page

2026-05-25T15:59:15Z

Skali:

Since documenting all of these novel substances with barely any information to go by can be a fairly challenging task, I will document my methods for creating wiki pages in here now.

Since the data on these substances is often heavily limited, the most important thing to go by is its chemical structure. In theory, every vector graphics editor like for instance the open-source program Inkscape or the popular closed-source alternative Adobe Illustrator would work to create vector images of chemical structures. Since this can become very tiresome very quickly, I however recommend the open source application '''MolSketch''' to create the basic organic structure of these compounds.

If you are on Linux, the easiest way to install MolSketch is by using Flatpak.
[[File:MolSketch flatpak screenshot.png|thumb|1098x1098px]]

If you are using macOS or Windows, you will have to grab the binary from SourceFourge.

https://github.com/hvennekate/Molsketch

https://sourceforge.net/projects/molsketch/files/latest/download

The UI might be a bit confusing at first, but don't worry, it's no steeper of a learning curve than Microsoft Paint.

Since a lot of research chemicals are based on already known drugs and pharmaceuticals, assuming you have successfully identified the core of the substance, you can save yourself a lot of time by searching for the ground molecule in the "Wikidata search" tab which is found in the toolbar to your left.
[[File:Screenshot showing the Wikidata function of MolSketch.png|thumb|393x393px]]
In order to identify which class of drug you have, it's recommended to familiarize yourself with the most common substance classes. Beware that not every pharmacologically active substance needs to be a derivative of another compound, fully synthetic compounds like the JWH series of cannabinoids, fentanyl or Z-drugs like Zolpidem do not resemble their sister compounds in their chemical structure, but still bind to the same receptors.

Wikipedia can be a good starting point if you need a quick reference on how a molecule looks, but as always, cross-check your information with other sources to verify that what you have on hand is actually what the source is claiming to be. Do not link to research chemical vendors as they are legally in a very ill defined grey area and could cause the Wiki some trouble.

[[File:Methane as symbolized in MolSketch.png|left|thumb|109x109px]]
If the compound doesn't resemble any other molecular structure, it's best to start off with a simple carbon atom. In order to place your first atom, use the toolbar on the top.

Let's get familiar with the most basic tools. The "Bar with a C at the top" is your atom and bond tool. Once you click it, a window will pop up asking you for the type of bond you want to add, and which atom you want to add to your structure. If you want to add a cyclic compound such as a phenyl group, you needn't draw them by hand. Simply click the triangle next to the atom and bond tool. In its drop down menu you can see all the different cyclic compounds available.
[[File:Molsketch explanation.webp|center|thumb|1040x1040px]]
[[File:MolSketch suggesting where to place the next atom.png|left|thumb|148x148px]]
Start drawing your molecule. Since MolSketch WILL let you freeform your molecules, I heavily recommended using its suggested placements. Once you click your first carbon atom and drag away from you, MolSketch will show you a bunch of possible neighboring atoms.

MolSketch will take care of the hydrogens and charges automatically, so you needn't worry about that for now. If you screwed up and would like to revert a change, you can either use the Ctrl + Z shortcut to revert to a state before your latest edit, or you can de-select the "atom and bonds" tool and simply click the offending atom, drag it around, or delete it using the Delete key.

Once your beautiful new molecule is all done and you saved the project to your hard disk using either the save button in the toolbar or Ctrl + S, it is time to turn it into a vector image that the MediaWiki software can understand.
[[File:File picker dialogue offering you to save as SVG.png|left|thumb]]
Using Ctrl + E you can export the file to an image. In the save file dialogue, you can choose between many different formats. Please always use "Scalable Vector Graphics" or "SVG" for short. This may look different depending on your operating system. The example here is shown under Linux running KDE Plasma.
[[File:Corrupted SVG produced by MolSketch.png|thumb]]
Great! Now you have created a SVG image of the molecule. However, some versions of MolSketch might produce ''slightly corrupted'' SVG images, which is why slight editing in another software suite, such as the free and open source Inkscape might be necessary.

As you can see, even thought the molecule itself was rendered correctly in MolSketch, the letters representing the individual non-carbon atoms are a bit off. This can easily be fixed however by resizing the letters and moving them into the center, similar to what the preview had produced.
[[File:InkScape dimensions for single letter atoms.png|thumb|For single letter atoms only[[File:InkScape settings for multi letter atoms.png|thumb|For atoms that have two letters (like chlorine)]]]]
Please make sure that all SINGLE LETTER atoms like Carbon, Oxygen or Nitrogen measure 3,00mm in width and 3,80mm in height. For DOUBLE LETTER atoms like Chlorine, Bromine or Iron, please make sure they measure 3,800mm in both width and height.

There is one last step before our beautiful little molecule friend is ready to be released onto the world. If you'd like, you can color in the atoms as to help distinguish them from the carbon structure.

The colors widely accepted by chemists go as such:

Oxygen

Nitrogen

Chlorine and Fluorine

Bromine

Phosphorus

Sulfur

Iodine

In case you have come across a very strange compound, the full list of colors to be used can be found at Wikipedia.
https://en.wikipedia.org/wiki/CPK_coloring
[[File:Inkscape resize without blank spaces.png|left|thumb]]

The last step before exporting the SVG in Inkscape is resizing the document to only contain the molecule and no unnecessary blank spaces. You can do this using the edit tab and selecting the option "Resize page to selection", or alternatively by pressing the hotkey combination of Shift + Ctrl + X.

And that's about it for now. This page will be amended with a short guide on how to verify your sources and where to find information and experience reports on very novel substances.

Wiki/How to make a good wiki page

2026-05-25T15:56:39Z

Skali: Bad wording fixed

Since documenting all of these novel substances with barely any information to go by can be a fairly challenging task, I will document my methods for creating wiki pages in here now.

Since the data on these substances is often heavily limited, the most important thing to go by is its chemical structure. In theory, every vector graphics editor like for instance the open-source program Inkscape or the popular closed-source alternative Adobe Illustrator would work to create vector images of chemical structures. Since this can become very tiresome very quickly, I however recommend the open source application '''MolSketch''' to create the basic organic structure of these compounds.

If you are on Linux, the easiest way to install MolSketch is by using Flatpak.
[[File:MolSketch flatpak screenshot.png|thumb|1098x1098px]]

If you are using macOS or Windows, you will have to grab the binary from SourceFourge.

https://github.com/hvennekate/Molsketch

https://sourceforge.net/projects/molsketch/files/latest/download

The UI might be a bit confusing at first, but don't worry, it's no steeper of a learning curve than Microsoft Paint.

Since a lot of research chemicals are based on already known drugs and pharmaceuticals, assuming you have successfully identified the core of the substance, you can save yourself a lot of time by searching for the ground molecule in the "Wikidata search" tab which is found in the toolbar to your left.
[[File:Screenshot showing the Wikidata function of MolSketch.png|thumb|393x393px]]
In order to identify which class of drug you have, it's recommended to familiarize yourself with the most common substance classes. Beware that not every pharmacologically active substance needs to be a derivative of another compound, fully synthetic compounds like the JWH series of cannabinoids, fentanyl or Z-drugs like Zolpidem do not resemble their sister compounds in their chemical structure, but still bind to the same receptors.

Wikipedia can be a good starting point if you need a quick reference on how a molecule looks, but as always, cross-check your information with other sources to verify that what you have on hand is actually what the source is claiming to be. Do not link to research chemical vendors as they are legally in a very ill defined grey area and could cause the Wiki some trouble.

[[File:Methane as symbolized in MolSketch.png|left|thumb|109x109px]]
If the compound doesn't resemble any other molecular structure, it's best to start off with a simple carbon atom. In order to place your first atom, use the toolbar on the top.

Let's get familiar with the most basic tools. The "Bar with a C at the top" is your atom and bond tool. Once you click it, a window will pop up asking you for the type of bond you want to add, and which atom you want to add to your structure. If you want to add a cyclic compound such as a phenyl group, you needn't draw them by hand. Simply click the triangle next to the atom and bond tool. In its drop down menu you can see all the different cyclic compounds available.
[[File:Molsketch explanation.webp|center|thumb|1040x1040px]]
[[File:MolSketch suggesting where to place the next atom.png|left|thumb|148x148px]]
Start drawing your molecule. Since MolSketch WILL let you freeform your molecules, I heavily recommended using its suggested placements. Once you click your first carbon atom and drag away from you, MolSketch will show you a bunch of possible neighboring atoms.

MolSketch will take care of the hydrogens and charges automatically, so you needn't worry about that for now. If you screwed up and would like to revert a change, you can either use the Ctrl + Z shortcut to revert to a state before your latest edit, or you can de-select the "atom and bonds" tool and simply click the offending atom, drag it around, or delete it using the Delete key.

Once your beautiful new molecule is all done and you saved the project to your hard disk using either the save button in the toolbar or Ctrl + S, it is time to turn it into a vector image that the MediaWiki software can understand.
[[File:File picker dialogue offering you to save as SVG.png|left|thumb]]
Using Ctrl + E you can export the file to an image. In the save file dialogue, you can choose between many different formats. Please always use "Scalable Vector Graphics" or "SVG" for short. This may look different depending on your operating system. The example here is shown under Linux running KDE Plasma.
[[File:Corrupted SVG produced by MolSketch.png|thumb]]
Great! Now you have created a SVG image of the molecule. However, some versions of MolSketch might produce ''slightly corrupted'' SVG images, which is why slight editing in another software suite, such as the free and open source Inkscape might be necessary.

As you can see, even thought the molecule itself was rendered correctly in MolSketch, the letters representing the individual non-carbon atoms are a bit off. This can easily be fixed however by resizing the letters and moving them into the center, similar to what the preview had produced.
[[File:InkScape dimensions for single letter atoms.png|thumb|For single letter atoms only[[File:InkScape settings for multi letter atoms.png|thumb|For atoms that have two letters (like chlorine)]]]]
Please make sure that all SINGLE LETTER atoms like Carbon, Oxygen or Nitrogen measure 3,00mm in width and 3,80mm in height. For DOUBLE LETTER atoms like Chlorine, Bromine or Iron, please make sure they measure 3,800mm in both width and height.

There is one last step before our beautiful little atom friend is ready to be released onto the world. If you'd like, you can color in the atoms as to help distinguish them from the carbon structure.

The colors widely accepted by chemists go as such:

Oxygen

Nitrogen

Chlorine and Fluorine

Bromine

Phosphorus

Sulfur

Iodine

In case you have come across a very strange compound, the full list of colors to be used can be found at Wikipedia.
https://en.wikipedia.org/wiki/CPK_coloring
[[File:Inkscape resize without blank spaces.png|left|thumb]]

The last step before exporting the SVG in Inkscape is resizing the document to only contain the molecule and no unnecessary blank spaces. You can do this using the edit tab and selecting the option "Resize page to selection", or alternatively by pressing the hotkey combination of Shift + Ctrl + X.

And that's about it for now. This page will be amended with a short guide on how to verify your sources and where to find information and experience reports on very novel substances.

Wiki/How to make a good wiki page

2026-05-25T15:55:54Z

Skali: Added colors, finished page for now

Since documenting all of these novel substances with barely any information to go by can be a fairly challenging task, I will document my methods for creating wiki pages in here now.

Since the data on these substances is often heavily limited, the most important thing to go by is its chemical structure. In theory, every vector graphics editor like for instance the open-source program Inkscape or the popular closed-source alternative Adobe Illustrator would work to create vector images of chemical structures. Since this can become very tiresome very quickly, I however recommend the open source application '''MolSketch''' to create the basic organic structure of these compounds.

If you are on Linux, the easiest way to install MolSketch is by using Flatpak.
[[File:MolSketch flatpak screenshot.png|thumb|1098x1098px]]

If you are using macOS or Windows, you will have to grab the binary from SourceFourge.

https://github.com/hvennekate/Molsketch

https://sourceforge.net/projects/molsketch/files/latest/download

The UI might be a bit confusing at first, but don't worry, it's no steeper of a learning curve than Microsoft Paint.

Since a lot of research chemicals are based on already known drugs and pharmaceuticals, and you have successfully identified the core of the substance, you can save yourself a lot of time by searching for the ground molecule in the "Wikidata search" tab which is found in the toolbar to your left.
[[File:Screenshot showing the Wikidata function of MolSketch.png|thumb|393x393px]]
In order to identify which class of drug you have, it's recommended to familiarize yourself with the most common substance classes. Beware that not every pharmacologically active substance needs to be a derivative of another compound, fully synthetic compounds like the JWH series of cannabinoids, fentanyl or Z-drugs like Zolpidem do not resemble their sister compounds in their chemical structure, but still bind to the same receptors.

Wikipedia can be a good starting point if you need a quick reference on how a molecule looks, but as always, cross-check your information with other sources to verify that what you have on hand is actually what the source is claiming to be. Do not link to research chemical vendors as they are legally in a very ill defined grey area and could cause the Wiki some trouble.

[[File:Methane as symbolized in MolSketch.png|left|thumb|109x109px]]
If the compound doesn't resemble any other molecular structure, it's best to start off with a simple carbon atom. In order to place your first atom, use the toolbar on the top.

Let's get familiar with the most basic tools. The "Bar with a C at the top" is your atom and bond tool. Once you click it, a window will pop up asking you for the type of bond you want to add, and which atom you want to add to your structure. If you want to add a cyclic compound such as a phenyl group, you needn't draw them by hand. Simply click the triangle next to the atom and bond tool. In its drop down menu you can see all the different cyclic compounds available.
[[File:Molsketch explanation.webp|center|thumb|1040x1040px]]
[[File:MolSketch suggesting where to place the next atom.png|left|thumb|148x148px]]
Start drawing your molecule. Since MolSketch WILL let you freeform your molecules, I heavily recommended using its suggested placements. Once you click your first carbon atom and drag away from you, MolSketch will show you a bunch of possible neighboring atoms.

MolSketch will take care of the hydrogens and charges automatically, so you needn't worry about that for now. If you screwed up and would like to revert a change, you can either use the Ctrl + Z shortcut to revert to a state before your latest edit, or you can de-select the "atom and bonds" tool and simply click the offending atom, drag it around, or delete it using the Delete key.

Once your beautiful new molecule is all done and you saved the project to your hard disk using either the save button in the toolbar or Ctrl + S, it is time to turn it into a vector image that the MediaWiki software can understand.
[[File:File picker dialogue offering you to save as SVG.png|left|thumb]]
Using Ctrl + E you can export the file to an image. In the save file dialogue, you can choose between many different formats. Please always use "Scalable Vector Graphics" or "SVG" for short. This may look different depending on your operating system. The example here is shown under Linux running KDE Plasma.
[[File:Corrupted SVG produced by MolSketch.png|thumb]]
Great! Now you have created a SVG image of the molecule. However, some versions of MolSketch might produce ''slightly corrupted'' SVG images, which is why slight editing in another software suite, such as the free and open source Inkscape might be necessary.

As you can see, even thought the molecule itself was rendered correctly in MolSketch, the letters representing the individual non-carbon atoms are a bit off. This can easily be fixed however by resizing the letters and moving them into the center, similar to what the preview had produced.
[[File:InkScape dimensions for single letter atoms.png|thumb|For single letter atoms only[[File:InkScape settings for multi letter atoms.png|thumb|For atoms that have two letters (like chlorine)]]]]
Please make sure that all SINGLE LETTER atoms like Carbon, Oxygen or Nitrogen measure 3,00mm in width and 3,80mm in height. For DOUBLE LETTER atoms like Chlorine, Bromine or Iron, please make sure they measure 3,800mm in both width and height.

There is one last step before our beautiful little atom friend is ready to be released onto the world. If you'd like, you can color in the atoms as to help distinguish them from the carbon structure.

The colors widely accepted by chemists go as such:

Oxygen

Nitrogen

Chlorine and Fluorine

Bromine

Phosphorus

Sulfur

Iodine

In case you have come across a very strange compound, the full list of colors to be used can be found at Wikipedia.
https://en.wikipedia.org/wiki/CPK_coloring
[[File:Inkscape resize without blank spaces.png|left|thumb]]

The last step before exporting the SVG in Inkscape is resizing the document to only contain the molecule and no unnecessary blank spaces. You can do this using the edit tab and selecting the option "Resize page to selection", or alternatively by pressing the hotkey combination of Shift + Ctrl + X.

And that's about it for now. This page will be amended with a short guide on how to verify your sources and where to find information and experience reports on very novel substances.

File:Inkscape resize without blank spaces.png

2026-05-25T15:53:37Z

Skali:

Inkscape resize without blank spaces

Wiki/How to make a good wiki page

2026-05-25T15:52:52Z

Skali:

Since documenting all of these novel substances with barely any information to go by can be a fairly challenging task, I will document my methods for creating wiki pages in here now.

Since the data on these substances is often heavily limited, the most important thing to go by is its chemical structure. In theory, every vector graphics editor like for instance the open-source program Inkscape or the popular closed-source alternative Adobe Illustrator would work to create vector images of chemical structures. Since this can become very tiresome very quickly, I however recommend the open source application '''MolSketch''' to create the basic organic structure of these compounds.

If you are on Linux, the easiest way to install MolSketch is by using Flatpak.
[[File:MolSketch flatpak screenshot.png|thumb|1098x1098px]]

If you are using macOS or Windows, you will have to grab the binary from SourceFourge.

https://github.com/hvennekate/Molsketch

https://sourceforge.net/projects/molsketch/files/latest/download

The UI might be a bit confusing at first, but don't worry, it's no steeper of a learning curve than Microsoft Paint.

Since a lot of research chemicals are based on already known drugs and pharmaceuticals, and you have successfully identified the core of the substance, you can save yourself a lot of time by searching for the ground molecule in the "Wikidata search" tab which is found in the toolbar to your left.
[[File:Screenshot showing the Wikidata function of MolSketch.png|thumb|393x393px]]
In order to identify which class of drug you have, it's recommended to familiarize yourself with the most common substance classes. Beware that not every pharmacologically active substance needs to be a derivative of another compound, fully synthetic compounds like the JWH series of cannabinoids, fentanyl or Z-drugs like Zolpidem do not resemble their sister compounds in their chemical structure, but still bind to the same receptors.

Wikipedia can be a good starting point if you need a quick reference on how a molecule looks, but as always, cross-check your information with other sources to verify that what you have on hand is actually what the source is claiming to be. Do not link to research chemical vendors as they are legally in a very ill defined grey area and could cause the Wiki some trouble.

[[File:Methane as symbolized in MolSketch.png|left|thumb|109x109px]]
If the compound doesn't resemble any other molecular structure, it's best to start off with a simple carbon atom. In order to place your first atom, use the toolbar on the top.

Let's get familiar with the most basic tools. The "Bar with a C at the top" is your atom and bond tool. Once you click it, a window will pop up asking you for the type of bond you want to add, and which atom you want to add to your structure. If you want to add a cyclic compound such as a phenyl group, you needn't draw them by hand. Simply click the triangle next to the atom and bond tool. In its drop down menu you can see all the different cyclic compounds available.
[[File:Molsketch explanation.webp|center|thumb|1040x1040px]]
[[File:MolSketch suggesting where to place the next atom.png|left|thumb|148x148px]]
Start drawing your molecule. Since MolSketch WILL let you freeform your molecules, I heavily recommended using its suggested placements. Once you click your first carbon atom and drag away from you, MolSketch will show you a bunch of possible neighboring atoms.

MolSketch will take care of the hydrogens and charges automatically, so you needn't worry about that for now. If you screwed up and would like to revert a change, you can either use the Ctrl + Z shortcut to revert to a state before your latest edit, or you can de-select the "atom and bonds" tool and simply click the offending atom, drag it around, or delete it using the Delete key.

Once your beautiful new molecule is all done and you saved the project to your hard disk using either the save button in the toolbar or Ctrl + S, it is time to turn it into a vector image that the MediaWiki software can understand.
[[File:File picker dialogue offering you to save as SVG.png|left|thumb]]
Using Ctrl + E you can export the file to an image. In the save file dialogue, you can choose between many different formats. Please always use "Scalable Vector Graphics" or "SVG" for short. This may look different depending on your operating system. The example here is shown under Linux running KDE Plasma.
[[File:Corrupted SVG produced by MolSketch.png|thumb]]
Great! Now you have created a SVG image of the molecule. However, some versions of MolSketch might produce ''slightly corrupted'' SVG images, which is why slight editing in another software suite, such as the free and open source Inkscape might be necessary.

As you can see, even thought the molecule itself was rendered correctly in MolSketch, the letters representing the individual non-carbon atoms are a bit off. This can easily be fixed however by resizing the letters and moving them into the center, similar to what the preview had produced.
[[File:InkScape dimensions for single letter atoms.png|thumb|For single letter atoms only[[File:InkScape settings for multi letter atoms.png|thumb|For atoms that have two letters (like chlorine)]]]]
Please make sure that all SINGLE LETTER atoms like Carbon, Oxygen or Nitrogen measure 3,00mm in width and 3,80mm in height. For DOUBLE LETTER atoms like Chlorine, Bromine or Iron, please make sure they measure 3,800mm in both width and height.

There is one last step before our beautiful little atom friend is ready to be released onto the world. If you'd like, you can color in the atoms as to help distinguish them from the carbon structure.

The colors widely accepted by chemists go as such:

Oxygen

Nitrogen

Chlorine and Fluorine

Bromine

Phosphorus

Sulfur

Iodine

In case you have come across a very strange compound, the full list of colors to be used can be found at Wikipedia.
https://en.wikipedia.org/wiki/CPK_coloring

The last step before exporting the SVG in Inkscape is resizing the document to only contain the molecule and no unnecessary blank spaces.

Wiki/How to make a good wiki page

2026-05-25T15:45:48Z

Skali: First pull, quick save to avoid progress loss

Since documenting all of these novel substances with barely any information to go by can be a fairly challenging task, I will document my methods for creating wiki pages in here now.

Since the data on these substances is often heavily limited, the most important thing to go by is its chemical structure. In theory, every vector graphics editor like for instance the open-source program Inkscape or the popular closed-source alternative Adobe Illustrator would work to create vector images of chemical structures. Since this can become very tiresome very quickly, I however recommend the open source application '''MolSketch''' to create the basic organic structure of these compounds.

If you are on Linux, the easiest way to install MolSketch is by using Flatpak.
[[File:MolSketch flatpak screenshot.png|thumb|1098x1098px]]

If you are using macOS or Windows, you will have to grab the binary from SourceFourge.

https://github.com/hvennekate/Molsketch

https://sourceforge.net/projects/molsketch/files/latest/download

The UI might be a bit confusing at first, but don't worry, it's no steeper of a learning curve than Microsoft Paint.

Since a lot of research chemicals are based on already known drugs and pharmaceuticals, and you have successfully identified the core of the substance, you can save yourself a lot of time by searching for the ground molecule in the "Wikidata search" tab which is found in the toolbar to your left.
[[File:Screenshot showing the Wikidata function of MolSketch.png|thumb|393x393px]]
In order to identify which class of drug you have, it's recommended to familiarize yourself with the most common substance classes. Beware that not every pharmacologically active substance needs to be a derivative of another compound, fully synthetic compounds like the JWH series of cannabinoids, fentanyl or Z-drugs like Zolpidem do not resemble their sister compounds in their chemical structure, but still bind to the same receptors.

Wikipedia can be a good starting point if you need a quick reference on how a molecule looks, but as always, cross-check your information with other sources to verify that what you have on hand is actually what the source is claiming to be. Do not link to research chemical vendors as they are legally in a very ill defined grey area and could cause the Wiki some trouble.

[[File:Methane as symbolized in MolSketch.png|left|thumb|109x109px]]
If the compound doesn't resemble any other molecular structure, it's best to start off with a simple carbon atom. In order to place your first atom, use the toolbar on the top.

Let's get familiar with the most basic tools. The "Bar with a C at the top" is your atom and bond tool. Once you click it, a window will pop up asking you for the type of bond you want to add, and which atom you want to add to your structure. If you want to add a cyclic compound such as a phenyl group, you needn't draw them by hand. Simply click the triangle next to the atom and bond tool. In its drop down menu you can see all the different cyclic compounds available.
[[File:Molsketch explanation.webp|center|thumb|1040x1040px]]
[[File:MolSketch suggesting where to place the next atom.png|left|thumb|148x148px]]
Start drawing your molecule. Since MolSketch WILL let you freeform your molecules, I heavily recommended using its suggested placements. Once you click your first carbon atom and drag away from you, MolSketch will show you a bunch of possible neighboring atoms.

MolSketch will take care of the hydrogens and charges automatically, so you needn't worry about that for now. If you screwed up and would like to revert a change, you can either use the Ctrl + Z shortcut to revert to a state before your latest edit, or you can de-select the "atom and bonds" tool and simply click the offending atom, drag it around, or delete it using the Delete key.

Once your beautiful new molecule is all done and you saved the project to your hard disk using either the save button in the toolbar or Ctrl + S, it is time to turn it into a vector image that the MediaWiki software can understand.
[[File:File picker dialogue offering you to save as SVG.png|left|thumb]]
Using Ctrl + E you can export the file to an image. In the save file dialogue, you can choose between many different formats. Please always use "Scalable Vector Graphics" or "SVG" for short. This may look different depending on your operating system. The example here is shown under Linux running KDE Plasma.
[[File:Corrupted SVG produced by MolSketch.png|thumb]]
Great! Now you have created a SVG image of the molecule. However, some versions of MolSketch might produce ''slightly corrupted'' SVG images, which is why slight editing in another software suite, such as the free and open source Inkscape might be necessary.

As you can see, even thought the molecule itself was rendered correctly in MolSketch, the letters representing the individual non-carbon atoms are a bit off. This can easily be fixed however by resizing the letters and moving them into the center, similar to what the preview had produced.
[[File:InkScape dimensions for single letter atoms.png|thumb|For single letter atoms only[[File:InkScape settings for multi letter atoms.png|thumb|For atoms that have two letters (like chlorine)]]]]
Please make sure that all SINGLE LETTER atoms like Carbon, Oxygen or Nitrogen measure 3,00mm in width and 3,80mm in height. For DOUBLE LETTER atoms like Chlorine, Bromine or Iron, please make sure they measure 3,800mm in both width and height.

There is one last step before our beautiful little atom friend is ready to be released onto the world. If you'd like, you can color in the atoms as to help distinguish them from the carbon structure.

The colors widely accepted by chemists go as such:

Nitrogen

File:InkScape settings for multi letter atoms.png

2026-05-25T15:42:15Z

Skali:

InkScape settings for multi letter atoms

File:InkScape dimensions for single letter atoms.png

2026-05-25T15:41:34Z

Skali:

InkScape dimensions for single letter atoms

File:Corrupted SVG produced by MolSketch.png

2026-05-25T15:39:27Z

Skali:

Corrupted SVG produced by MolSketch

File:File picker dialogue offering you to save as SVG.png

2026-05-25T15:37:34Z

Skali:

File picker dialogue offering you to save as SVG

File:MolSketch suggesting where to place the next atom.png

2026-05-25T15:29:14Z

Skali:

MolSketch suggesting where to place the next atom

File:Molsketch explanation.webp

2026-05-25T15:25:23Z

Skali:

Molsketch explanation

File:Methane as symbolized in MolSketch.png

2026-05-25T15:07:03Z

Skali:

Methane as symbolized in MolSketch

File:Screenshot showing the Wikidata function of MolSketch.png

2026-05-25T15:01:38Z

Skali:

Screenshot showing the Wikidata function of MolSketch

File:MolSketch flatpak screenshot.png

2026-05-25T14:57:29Z

Skali:

MolSketch flatpak screenshot

Wiki/N-Phenethyl-Noroxymorphone

2026-05-12T12:56:06Z

Skali: Made chemistry into a category

'''N-Phenethyl-Noroxymorphone''', also known by its acronym '''PHM''', is an extremely potent opioid of the morphinan class.
[[File:N-phenethyl-noroxymorphone.svg|thumb|alt=An image of the chemical structure of N-Phenethyl-Noroxymorphone|The chemical structure of N-Phenethyl-Noroxymorphone]]
Chemically it can be described as similar to opioid receptor antagonists such as Naloxone or Naltrexone, however, despite the chemical reassemblence, strongly activates the µ-Opioid receptors.<ref>A Comparative Analysis of N-Phenethylnoroxymorphone and Fentanyl Potency at the Mu-Opioid Receptor by BenchChem Technical Support Team. Released April 2026. Last fetched at 11 May 2026. Full text available at: https://pdf.benchchem.com/15621/A_Comparative_Analysis_of_N_Phenethylnoroxymorphone_and_Fentanyl_Potency_at_the_Mu_Opioid_Receptor.pdf</ref> It has been encountered in research chemical shops in Germany and is as of May 2026 not federally scheduled there. PHM displays the same behavior as other opioid agonists, in that it leads to β-Arrestin 2 recruitment, so dependency and withdrawal if use of this substance is discontinued should be comparable to other more classical opioids such as fentanyl or morphine. The molecule is highly lipophilic due to the addition of a phenylethyl group, therefore it can penetrate the synaptic cleft stronger than a traditional opiate would. This effect is also visible with one of its '''sister compounds''' it is very closely related to, ''N-Phenethyl-Normorphine.''<ref>Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM (February 2000). "Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor". Journal of Medicinal Chemistry. 43 (3): 381–91. doi:10.1021/jm9903702. PMID 10669565.</ref><ref>McFadyen I, Metzger T, Subramanian G, Poda G, Jorvig E, Ferguson DM (2002). Molecular modeling of opioid receptor-ligand complexes. Progress in Medicinal Chemistry. Vol. 40. pp. 107–35. doi:10.1016/S0079-6468(08)70083-3. ISBN 9780444510549. PMID 12516524.</ref> The compound, while being new to the research chemical market, has first been synthesized in the 1960s as a potent analgesic, but was never marketed.<ref>NPS Discovery - New Drug Monograph - N-Phenethyl Noroxymorphone. Center for Forensic Science Research & Education. 21 August 2024. Retrieved at 11 May 2026. Available at: https://www.drugsandalcohol.ie/41985/1/N-Phenethyl-Noroxymorphone-New-Drug-Monograph-NPS-Discovery.pdf</ref> Like many other drugs, its appearance can be described as a white powder without any notable odors or discolorations mentioned.

=== Pharmacology ===

PHM is highly selective for the mu-opioid receptor over the kappa-opioid receptor and presents roughly 2x the affinity and potency at the mu-opioid receptors that oxymorphone exhibits. There exists no reliable data on the equianalgesic doses of PHM yet, however, its parent compound oxymorphone has very much been studied extensively.
{| class="wikitable sortable"
|+Equianalgesic doses<ref>King TL, Miller EL (25 October 2010). "Analgesia and Anesthesia". In King TL, Brucker MC (eds.). Pharmacology for Women's Health. Jones & Bartlett Publishers. pp. 332–. ISBN 978-1-4496-1073-9.</ref><ref>Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre J (28 February 2014). Chestnut's Obstetric Anesthesia: Principles and Practice E-Book. Elsevier Health Sciences. pp. 611–. ISBN 978-0-323-11374-8.</ref><ref>Tiziani AP (1 June 2013). Havard's Nursing Guide to Drugs. Elsevier Health Sciences. pp. 933–. ISBN 978-0-7295-8162-2.</ref>
!Compound
!Route of administration
!Dose
|-
|Morphine
|Oral
|30mg
|-
|Oxymorphone
|Oral
|7-10mg
|-
|Oxymorphone
|IV (Intravenous)
|1mg
|-
|PHM (Assumed)
|Oral
|5mg
|-
|PHM (Assumed)
|IV (Intravenous)
|500µg
|}
Since potency at the receptor roughly translate to the analgesic properties of a drug, we can assume that 5mg orally or 500µg intravenously to be equivalent to an oral administration of 30mg of morphine.

=== Chemistry ===
PHM is a Morphinan, means it shares the same core structure that naturally sourced opiates share.

'''Basic data:'''

* '''CAS-Number:''' 4778-94-3
* '''IUPAC Name:''' (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-(2-phenylethyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
* '''InChl Key:''' NDHIGBQXQCVRAU-QLBRKBSLSA-N
* '''Formula:''' C24H25NO4
* '''Molecular weight:''' 391.5

Wiki/N-Phenethyl-Noroxymorphone

2026-05-12T12:55:42Z

Skali: Added basic chemistry data

'''N-Phenethyl-Noroxymorphone''', also known by its acronym '''PHM''', is an extremely potent opioid of the morphinan class.
[[File:N-phenethyl-noroxymorphone.svg|thumb|alt=An image of the chemical structure of N-Phenethyl-Noroxymorphone|The chemical structure of N-Phenethyl-Noroxymorphone]]
Chemically it can be described as similar to opioid receptor antagonists such as Naloxone or Naltrexone, however, despite the chemical reassemblence, strongly activates the µ-Opioid receptors.<ref>A Comparative Analysis of N-Phenethylnoroxymorphone and Fentanyl Potency at the Mu-Opioid Receptor by BenchChem Technical Support Team. Released April 2026. Last fetched at 11 May 2026. Full text available at: https://pdf.benchchem.com/15621/A_Comparative_Analysis_of_N_Phenethylnoroxymorphone_and_Fentanyl_Potency_at_the_Mu_Opioid_Receptor.pdf</ref> It has been encountered in research chemical shops in Germany and is as of May 2026 not federally scheduled there. PHM displays the same behavior as other opioid agonists, in that it leads to β-Arrestin 2 recruitment, so dependency and withdrawal if use of this substance is discontinued should be comparable to other more classical opioids such as fentanyl or morphine. The molecule is highly lipophilic due to the addition of a phenylethyl group, therefore it can penetrate the synaptic cleft stronger than a traditional opiate would. This effect is also visible with one of its '''sister compounds''' it is very closely related to, ''N-Phenethyl-Normorphine.''<ref>Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM (February 2000). "Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor". Journal of Medicinal Chemistry. 43 (3): 381–91. doi:10.1021/jm9903702. PMID 10669565.</ref><ref>McFadyen I, Metzger T, Subramanian G, Poda G, Jorvig E, Ferguson DM (2002). Molecular modeling of opioid receptor-ligand complexes. Progress in Medicinal Chemistry. Vol. 40. pp. 107–35. doi:10.1016/S0079-6468(08)70083-3. ISBN 9780444510549. PMID 12516524.</ref> The compound, while being new to the research chemical market, has first been synthesized in the 1960s as a potent analgesic, but was never marketed.<ref>NPS Discovery - New Drug Monograph - N-Phenethyl Noroxymorphone. Center for Forensic Science Research & Education. 21 August 2024. Retrieved at 11 May 2026. Available at: https://www.drugsandalcohol.ie/41985/1/N-Phenethyl-Noroxymorphone-New-Drug-Monograph-NPS-Discovery.pdf</ref> Like many other drugs, its appearance can be described as a white powder without any notable odors or discolorations mentioned.

=== Pharmacology ===

PHM is highly selective for the mu-opioid receptor over the kappa-opioid receptor and presents roughly 2x the affinity and potency at the mu-opioid receptors that oxymorphone exhibits. There exists no reliable data on the equianalgesic doses of PHM yet, however, its parent compound oxymorphone has very much been studied extensively.
{| class="wikitable sortable"
|+Equianalgesic doses<ref>King TL, Miller EL (25 October 2010). "Analgesia and Anesthesia". In King TL, Brucker MC (eds.). Pharmacology for Women's Health. Jones & Bartlett Publishers. pp. 332–. ISBN 978-1-4496-1073-9.</ref><ref>Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre J (28 February 2014). Chestnut's Obstetric Anesthesia: Principles and Practice E-Book. Elsevier Health Sciences. pp. 611–. ISBN 978-0-323-11374-8.</ref><ref>Tiziani AP (1 June 2013). Havard's Nursing Guide to Drugs. Elsevier Health Sciences. pp. 933–. ISBN 978-0-7295-8162-2.</ref>
!Compound
!Route of administration
!Dose
|-
|Morphine
|Oral
|30mg
|-
|Oxymorphone
|Oral
|7-10mg
|-
|Oxymorphone
|IV (Intravenous)
|1mg
|-
|PHM (Assumed)
|Oral
|5mg
|-
|PHM (Assumed)
|IV (Intravenous)
|500µg
|}
Since potency at the receptor roughly translate to the analgesic properties of a drug, we can assume that 5mg orally or 500µg intravenously to be equivalent to an oral administration of 30mg of morphine.

== Chemistry ==
PHM is a Morphinan, means it shares the same core structure that naturally sourced opiates share.

'''Basic data:'''

* '''CAS-Number:''' 4778-94-3
* '''IUPAC Name:''' (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-(2-phenylethyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
* '''InChl Key:''' NDHIGBQXQCVRAU-QLBRKBSLSA-N
* '''Formula:''' C24H25NO4
* '''Molecular weight:''' 391.5

Wiki/N-Phenethyl-Noroxymorphone

2026-05-11T14:15:16Z

Skali:

Wiki/N-Phenethyl-Noroxymorphone

2026-05-11T14:14:49Z

Skali: Added image

'''N-Phenethyl-Noroxymorphone''', also known by its acronym '''PHM''', is an extremely potent opioid of the morphinan class.
[[File:N-phenethyl-noroxymorphone.svg|thumb]]
Chemically it can be described as similar to opioid receptor antagonists such as Naloxone or Naltrexone, however, despite the chemical reassemblence, strongly activates the µ-Opioid receptors.<ref>A Comparative Analysis of N-Phenethylnoroxymorphone and Fentanyl Potency at the Mu-Opioid Receptor by BenchChem Technical Support Team. Released April 2026. Last fetched at 11 May 2026. Full text available at: https://pdf.benchchem.com/15621/A_Comparative_Analysis_of_N_Phenethylnoroxymorphone_and_Fentanyl_Potency_at_the_Mu_Opioid_Receptor.pdf</ref> It has been encountered in research chemical shops in Germany and is as of May 2026 not federally scheduled there. PHM displays the same behavior as other opioid agonists, in that it leads to β-Arrestin 2 recruitment, so dependency and withdrawal if use of this substance is discontinued should be comparable to other more classical opioids such as fentanyl or morphine. The molecule is highly lipophilic due to the addition of a phenylethyl group, therefore it can penetrate the synaptic cleft stronger than a traditional opiate would. This effect is also visible with one of its '''sister compounds''' it is very closely related to, ''N-Phenethyl-Normorphine.''<ref>Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM (February 2000). "Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor". Journal of Medicinal Chemistry. 43 (3): 381–91. doi:10.1021/jm9903702. PMID 10669565.</ref><ref>McFadyen I, Metzger T, Subramanian G, Poda G, Jorvig E, Ferguson DM (2002). Molecular modeling of opioid receptor-ligand complexes. Progress in Medicinal Chemistry. Vol. 40. pp. 107–35. doi:10.1016/S0079-6468(08)70083-3. ISBN 9780444510549. PMID 12516524.</ref> The compound, while being new to the research chemical market, has first been synthesized in the 1960s as a potent analgesic, but was never marketed.<ref>NPS Discovery - New Drug Monograph - N-Phenethyl Noroxymorphone. Center for Forensic Science Research & Education. 21 August 2024. Retrieved at 11 May 2026. Available at: https://www.drugsandalcohol.ie/41985/1/N-Phenethyl-Noroxymorphone-New-Drug-Monograph-NPS-Discovery.pdf</ref> Like many other drugs, its appearance can be described as a white powder without any notable odors or discolorations mentioned.

=== Pharmacology ===

PHM is highly selective for the mu-opioid receptor over the kappa-opioid receptor and presents roughly 2x the affinity and potency at the mu-opioid receptors that oxymorphone exhibits. There exists no reliable data on the equianalgesic doses of PHM yet, however, its parent compound oxymorphone has very much been studied extensively.
{| class="wikitable sortable"
|+Equianalgesic doses<ref>King TL, Miller EL (25 October 2010). "Analgesia and Anesthesia". In King TL, Brucker MC (eds.). Pharmacology for Women's Health. Jones & Bartlett Publishers. pp. 332–. ISBN 978-1-4496-1073-9.</ref><ref>Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre J (28 February 2014). Chestnut's Obstetric Anesthesia: Principles and Practice E-Book. Elsevier Health Sciences. pp. 611–. ISBN 978-0-323-11374-8.</ref><ref>Tiziani AP (1 June 2013). Havard's Nursing Guide to Drugs. Elsevier Health Sciences. pp. 933–. ISBN 978-0-7295-8162-2.</ref>
!Compound
!Route of administration
!Dose
|-
|Morphine
|Oral
|30mg
|-
|Oxymorphone
|Oral
|7-10mg
|-
|Oxymorphone
|IV (Intravenous)
|1mg
|-
|PHM (Assumed)
|Oral
|5mg
|-
|PHM (Assumed)
|IV (Intravenous)
|500µg
|}
Since potency at the receptor roughly translate to the analgesic properties of a drug, we can assume that 5mg orally or 500µg intravenously to be equivalent to an oral administration of 30mg of morphine.

File:N-phenethyl-noroxymorphone.svg

2026-05-11T14:14:37Z

Skali:

N-phenethyl-noroxymorphone

Wiki/N-Phenethyl-Noroxymorphone

2026-05-11T14:13:52Z

Skali: Added equivalent doses of morphine for comparision

'''N-Phenethyl-Noroxymorphone''', also known by its acronym '''PHM''', is an extremely potent opioid of the morphinan class. Chemically it can be described as similar to opioid receptor antagonists such as Naloxone or Naltrexone, however, despite the chemical reassemblence, strongly activates the µ-Opioid receptors.<ref>A Comparative Analysis of N-Phenethylnoroxymorphone and Fentanyl Potency at the Mu-Opioid Receptor by BenchChem Technical Support Team. Released April 2026. Last fetched at 11 May 2026. Full text available at: https://pdf.benchchem.com/15621/A_Comparative_Analysis_of_N_Phenethylnoroxymorphone_and_Fentanyl_Potency_at_the_Mu_Opioid_Receptor.pdf</ref> It has been encountered in research chemical shops in Germany and is as of May 2026 not federally scheduled there. PHM displays the same behavior as other opioid agonists, in that it leads to β-Arrestin 2 recruitment, so dependency and withdrawal if use of this substance is discontinued should be comparable to other more classical opioids such as fentanyl or morphine. The molecule is highly lipophilic due to the addition of a phenylethyl group, therefore it can penetrate the synaptic cleft stronger than a traditional opiate would. This effect is also visible with one of its '''sister compounds''' it is very closely related to, ''N-Phenethyl-Normorphine.''<ref>Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM (February 2000). "Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor". Journal of Medicinal Chemistry. 43 (3): 381–91. doi:10.1021/jm9903702. PMID 10669565.</ref><ref>McFadyen I, Metzger T, Subramanian G, Poda G, Jorvig E, Ferguson DM (2002). Molecular modeling of opioid receptor-ligand complexes. Progress in Medicinal Chemistry. Vol. 40. pp. 107–35. doi:10.1016/S0079-6468(08)70083-3. ISBN 9780444510549. PMID 12516524.</ref> The compound, while being new to the research chemical market, has first been synthesized in the 1960s as a potent analgesic, but was never marketed.<ref>NPS Discovery - New Drug Monograph - N-Phenethyl Noroxymorphone. Center for Forensic Science Research & Education. 21 August 2024. Retrieved at 11 May 2026. Available at: https://www.drugsandalcohol.ie/41985/1/N-Phenethyl-Noroxymorphone-New-Drug-Monograph-NPS-Discovery.pdf</ref> Like many other drugs, its appearance can be described as a white powder without any notable odors or discolorations mentioned.

=== Pharmacology ===

PHM is highly selective for the mu-opioid receptor over the kappa-opioid receptor and presents roughly 2x the affinity and potency at the mu-opioid receptors that oxymorphone exhibits. There exists no reliable data on the equianalgesic doses of PHM yet, however, its parent compound oxymorphone has very much been studied extensively.
{| class="wikitable sortable"
|+Equianalgesic doses<ref>King TL, Miller EL (25 October 2010). "Analgesia and Anesthesia". In King TL, Brucker MC (eds.). Pharmacology for Women's Health. Jones & Bartlett Publishers. pp. 332–. ISBN 978-1-4496-1073-9.</ref><ref>Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre J (28 February 2014). Chestnut's Obstetric Anesthesia: Principles and Practice E-Book. Elsevier Health Sciences. pp. 611–. ISBN 978-0-323-11374-8.</ref><ref>Tiziani AP (1 June 2013). Havard's Nursing Guide to Drugs. Elsevier Health Sciences. pp. 933–. ISBN 978-0-7295-8162-2.</ref>
!Compound
!Route of administration
!Dose
|-
|Morphine
|Oral
|30mg
|-
|Oxymorphone
|Oral
|7-10mg
|-
|Oxymorphone
|IV (Intravenous)
|1mg
|-
|PHM (Assumed)
|Oral
|5mg
|-
|PHM (Assumed)
|IV (Intravenous)
|500µg
|}
Since potency at the receptor roughly translate to the analgesic properties of a drug, we can assume that 5mg orally or 500µg intravenously to be equivalent to an oral administration of 30mg of morphine.

Wiki/N-Phenethyl-Noroxymorphone

2026-05-11T14:07:34Z

Skali: Created page with "'''N-Phenethyl-Noroxymorphone''', also known by its acronym '''PHM''', is an extremely potent opioid of the morphinan class. Chemically it can be described as similar to opioid receptor antagonists such as Naloxone or Naltrexone, however, despite the chemical reassemblence, strongly activates the µ-Opioid receptors.<ref>A Comparative Analysis of N-Phenethylnoroxymorphone and Fentanyl Potency at the Mu-Opioid Receptor by BenchChem Technical Support Team. Released April 2..."

Substance:Alpravalzafone

2026-05-11T13:40:57Z

Skali:

Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Full text available here: https://www.researchgate.net/publication/399189249_Monitoring_rynka_psihoaktivnoj_produkcii_Analiz_tendencij_Vypusk_72_Dekabr_2025_azyk_-_russkij</ref>

[[File:Alpravalzafone without regards to geometry.svg|thumb|alt=Chemical structure of Alpravalzafone (Without regards to geometry)|Chemical structure of Alpravalzafone (Without regards to geometry)]]

It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone. Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam.<ref>Posted on Reddit by user u/Capable_Sugar_5806 on 14th of April 2026: https://old.reddit.com/r/researchchemicals_DE/comments/1sl9nwr/alpravalzafone_positiver_laborbefund_auf_mehrere/</ref> It is hereby unclear why the report includes the metabolite Oxazepam, as Alpravalzafone cannot metabolize into Oxazepam under normal conditions due to the addition of a triazolo group (the pentyl ring containing three nitrogens at the very top of the molecule), so contamination by the vendor or cross-contamination from other drugs may be possible here.

It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure. The compound was described in scientific literature by Aipsin (A Russian anti-narcotics company) as early as March of 2026, turning up in the first RC Vendor's stores shortly thereafter.

=== Dosage ===
The exact active dose is unclear, however, assuming full metabolism of the prodrug in the bloodstream, comparing the molecular weights, we can estimate that roughly 64% of the prodrug gets converted to Alprazolam.

Alprazolam's molecular weight: 308.77 g/mol

Alpravalzafone's molecular weight: 482.38g/mol

Therefore:
308.77/482.38 = 0.6400970189 ~ 64%

It is unclear what exactly the redundant metabolites of this prodrug are, so currently use is not advised. It is likely this prodrug releases either isoleucineamide or isoleucine, as there are only five carbon atoms required to close the diazepine ring. No reliable reports on the metabolism of this prodrug have yet been encountered.

=== Chemistry ===

'''Basic data:'''

Formula: C22H25Cl2N5O2

Molar mass: 462.38g/mol

SMILES: NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C

Systemic IUPAC name: 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid

'''Solubility:'''

According to a user on eve&rave.ch, the powdered version of Alpravalzafone is very soluble in a 37,5% ethanol in water solution. Please note that co-ingestion of benzodiazepines with larger amounts of ethanol may posses additional dangers.<ref>Posted on 21. February 2026 by user pincone on eve&rave: https://forum.eve-rave.ch/viewtopic.php?t=83423</ref>

In a test performed by the editor, Alpravalzafone hydrochloride completely dissolved in both descaled tap water as well as a 99,9% pure propylene glycol solution.

=== Legal status ===
Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however, would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and hydrolizes back into the closed ring form.

Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. Full text available at: https://aipsin.com/newsubstance/1931/</ref>

=== Sources ===
<references />
[[Category:Benzodiazepines]]
[[Category:Depressants]]
[[Category:Research chemicals]]
[[Category:Substances]]
__INDEX__

Substance:Alpravalzafone

2026-05-11T13:40:45Z

Skali:

DISPLAYTITLE

Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Full text available here: https://www.researchgate.net/publication/399189249_Monitoring_rynka_psihoaktivnoj_produkcii_Analiz_tendencij_Vypusk_72_Dekabr_2025_azyk_-_russkij</ref>

[[File:Alpravalzafone without regards to geometry.svg|thumb|alt=Chemical structure of Alpravalzafone (Without regards to geometry)|Chemical structure of Alpravalzafone (Without regards to geometry)]]

It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone. Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam.<ref>Posted on Reddit by user u/Capable_Sugar_5806 on 14th of April 2026: https://old.reddit.com/r/researchchemicals_DE/comments/1sl9nwr/alpravalzafone_positiver_laborbefund_auf_mehrere/</ref> It is hereby unclear why the report includes the metabolite Oxazepam, as Alpravalzafone cannot metabolize into Oxazepam under normal conditions due to the addition of a triazolo group (the pentyl ring containing three nitrogens at the very top of the molecule), so contamination by the vendor or cross-contamination from other drugs may be possible here.

It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure. The compound was described in scientific literature by Aipsin (A Russian anti-narcotics company) as early as March of 2026, turning up in the first RC Vendor's stores shortly thereafter.

=== Dosage ===
The exact active dose is unclear, however, assuming full metabolism of the prodrug in the bloodstream, comparing the molecular weights, we can estimate that roughly 64% of the prodrug gets converted to Alprazolam.

Alprazolam's molecular weight: 308.77 g/mol

Alpravalzafone's molecular weight: 482.38g/mol

Therefore:
308.77/482.38 = 0.6400970189 ~ 64%

It is unclear what exactly the redundant metabolites of this prodrug are, so currently use is not advised. It is likely this prodrug releases either isoleucineamide or isoleucine, as there are only five carbon atoms required to close the diazepine ring. No reliable reports on the metabolism of this prodrug have yet been encountered.

=== Chemistry ===

'''Basic data:'''

Formula: C22H25Cl2N5O2

Molar mass: 462.38g/mol

SMILES: NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C

Systemic IUPAC name: 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid

'''Solubility:'''

According to a user on eve&rave.ch, the powdered version of Alpravalzafone is very soluble in a 37,5% ethanol in water solution. Please note that co-ingestion of benzodiazepines with larger amounts of ethanol may posses additional dangers.<ref>Posted on 21. February 2026 by user pincone on eve&rave: https://forum.eve-rave.ch/viewtopic.php?t=83423</ref>

In a test performed by the editor, Alpravalzafone hydrochloride completely dissolved in both descaled tap water as well as a 99,9% pure propylene glycol solution.

=== Legal status ===
Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however, would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and hydrolizes back into the closed ring form.

Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. Full text available at: https://aipsin.com/newsubstance/1931/</ref>

=== Sources ===
<references />
[[Category:Benzodiazepines]]
[[Category:Depressants]]
[[Category:Research chemicals]]
[[Category:Substances]]
__INDEX__

Substance:Alpravalzafone

2026-05-11T13:40:23Z

Skali:

Substance:Alpravalzafone

2026-05-11T13:40:11Z

Skali: Added categories, made page title more appealing

Substance:Alpravalzafone

2026-05-11T13:35:28Z

Skali: Add possibility of isoleucine as a metabolite

Substance:Alpravalzafone

2026-05-11T11:11:17Z

Skali: Rectified statement about my own test

Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Full text available here: https://www.researchgate.net/publication/399189249_Monitoring_rynka_psihoaktivnoj_produkcii_Analiz_tendencij_Vypusk_72_Dekabr_2025_azyk_-_russkij</ref>

[[File:Alpravalzafone without regards to geometry.svg|thumb|alt=Chemical structure of Alpravalzafone (Without regards to geometry)|Chemical structure of Alpravalzafone (Without regards to geometry)]]

It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone. Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam.<ref>Posted on Reddit by user u/Capable_Sugar_5806 on 14th of April 2026: https://old.reddit.com/r/researchchemicals_DE/comments/1sl9nwr/alpravalzafone_positiver_laborbefund_auf_mehrere/</ref> It is hereby unclear why the report includes the metabolite Oxazepam, as Alpravalzafone cannot metabolize into Oxazepam under normal conditions due to the addition of a triazolo group (the pentyl ring containing three nitrogens at the very top of the molecule), so contamination by the vendor or cross-contamination from other drugs may be possible here.

It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure. The compound was described in scientific literature by Aipsin (A Russian anti-narcotics company) as early as March of 2026, turning up in the first RC Vendor's stores shortly thereafter.

=== Dosage ===
The exact active dose is unclear, however, assuming full metabolism of the prodrug in the bloodstream, comparing the molecular weights, we can estimate that roughly 64% of the prodrug gets converted to Alprazolam.

Alprazolam's molecular weight: 308.77 g/mol

Alpravalzafone's molecular weight: 482.38g/mol

Therefore:
308.77/482.38 = 0.6400970189 ~ 64%

It is unclear what exactly the redundant metabolites of this prodrug are, so currently use is not advised.

=== Chemistry ===

'''Basic data:'''

Formula: C22H25Cl2N5O2

Molar mass: 462.38g/mol

SMILES: NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C

Systemic IUPAC name: 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid

'''Solubility:'''

According to a user on eve&rave.ch, the powdered version of Alpravalzafone is very soluble in a 37,5% ethanol in water solution. Please note that co-ingestion of benzodiazepines with larger amounts of ethanol may posses additional dangers.<ref>Posted on 21. February 2026 by user pincone on eve&rave: https://forum.eve-rave.ch/viewtopic.php?t=83423</ref>

In a test performed by the editor, Alpravalzafone hydrochloride completely dissolved in both descaled tap water as well as a 99,9% pure propylene glycol solution.

=== Legal status ===
Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however, would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and hydrolizes back into the closed ring form.

Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. Full text available at: https://aipsin.com/newsubstance/1931/</ref>

=== Sources ===
<references />

Substance:Alpravalzafone

2026-05-11T11:10:48Z

Skali: Added newlines

Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Full text available here: https://www.researchgate.net/publication/399189249_Monitoring_rynka_psihoaktivnoj_produkcii_Analiz_tendencij_Vypusk_72_Dekabr_2025_azyk_-_russkij</ref>

[[File:Alpravalzafone without regards to geometry.svg|thumb|alt=Chemical structure of Alpravalzafone (Without regards to geometry)|Chemical structure of Alpravalzafone (Without regards to geometry)]]

It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone. Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam.<ref>Posted on Reddit by user u/Capable_Sugar_5806 on 14th of April 2026: https://old.reddit.com/r/researchchemicals_DE/comments/1sl9nwr/alpravalzafone_positiver_laborbefund_auf_mehrere/</ref> It is hereby unclear why the report includes the metabolite Oxazepam, as Alpravalzafone cannot metabolize into Oxazepam under normal conditions due to the addition of a triazolo group (the pentyl ring containing three nitrogens at the very top of the molecule), so contamination by the vendor or cross-contamination from other drugs may be possible here.

It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure. The compound was described in scientific literature by Aipsin (A Russian anti-narcotics company) as early as March of 2026, turning up in the first RC Vendor's stores shortly thereafter.

=== Dosage ===
The exact active dose is unclear, however, assuming full metabolism of the prodrug in the bloodstream, comparing the molecular weights, we can estimate that roughly 64% of the prodrug gets converted to Alprazolam.

Alprazolam's molecular weight: 308.77 g/mol

Alpravalzafone's molecular weight: 482.38g/mol

Therefore:
308.77/482.38 = 0.6400970189 ~ 64%

It is unclear what exactly the redundant metabolites of this prodrug are, so currently use is not advised.

=== Chemistry ===

'''Basic data:'''

Formula: C22H25Cl2N5O2

Molar mass: 462.38g/mol

SMILES: NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C

Systemic IUPAC name: 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid

'''Solubility:'''

According to a user on eve&rave.ch, the powdered version of Alpravalzafone is very soluble in a 37,5% ethanol in water solution. Please note that co-ingestion of benzodiazepines with larger amounts of ethanol may posses additional dangers.<ref>Posted on 21. February 2026 by user pincone on eve&rave: https://forum.eve-rave.ch/viewtopic.php?t=83423</ref>

In a test performed by the editor, Alpravalzafone completely dissolved in both descaled tap water as well as a 99,9% pure propylene glycol solution.

=== Legal status ===
Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however, would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and hydrolizes back into the closed ring form.

Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. Full text available at: https://aipsin.com/newsubstance/1931/</ref>

=== Sources ===
<references />

Substance:Alpravalzafone

2026-05-11T11:10:22Z

Skali:

Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Full text available here: https://www.researchgate.net/publication/399189249_Monitoring_rynka_psihoaktivnoj_produkcii_Analiz_tendencij_Vypusk_72_Dekabr_2025_azyk_-_russkij</ref>

[[File:Alpravalzafone without regards to geometry.svg|thumb|alt=Chemical structure of Alpravalzafone (Without regards to geometry)|Chemical structure of Alpravalzafone (Without regards to geometry)]]

It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone. Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam.<ref>Posted on Reddit by user u/Capable_Sugar_5806 on 14th of April 2026: https://old.reddit.com/r/researchchemicals_DE/comments/1sl9nwr/alpravalzafone_positiver_laborbefund_auf_mehrere/</ref> It is hereby unclear why the report includes the metabolite Oxazepam, as Alpravalzafone cannot metabolize into Oxazepam under normal conditions due to the addition of a triazolo group (the pentyl ring containing three nitrogens at the very top of the molecule), so contamination by the vendor or cross-contamination from other drugs may be possible here.

It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure. The compound was described in scientific literature by Aipsin (A Russian anti-narcotics company) as early as March of 2026, turning up in the first RC Vendor's stores shortly thereafter.

=== Dosage ===
The exact active dose is unclear, however, assuming full metabolism of the prodrug in the bloodstream, comparing the molecular weights, we can estimate that roughly 64% of the prodrug gets converted to Alprazolam.

Alprazolam's molecular weight: 308.77 g/mol

Alpravalzafone's molecular weight: 482.38g/mol

Therefore:
308.77/482.38 = 0.6400970189 ~ 64%

It is unclear what exactly the redundant metabolites of this prodrug are, so currently use is not advised.

=== Chemistry ===

'''Basic data:'''
Formula: C22H25Cl2N5O2
Molar mass: 462.38g/mol
SMILES: NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C
Systemic IUPAC name: 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid

'''Solubility:'''
According to a user on eve&rave.ch, the powdered version of Alpravalzafone is very soluble in a 37,5% ethanol in water solution. Please note that co-ingestion of benzodiazepines with larger amounts of ethanol may posses additional dangers.<ref>Posted on 21. February 2026 by user pincone on eve&rave: https://forum.eve-rave.ch/viewtopic.php?t=83423</ref>

In a test performed by the editor, Alpravalzafone completely dissolved in both descaled tap water as well as a 99,9% pure propylene glycol solution.

=== Legal status ===
Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however, would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and hydrolizes back into the closed ring form.

Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. Full text available at: https://aipsin.com/newsubstance/1931/</ref>

=== Sources ===
<references />

Substance:Alpravalzafone

2026-05-11T11:10:04Z

Skali:

Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Full text available here: https://www.researchgate.net/publication/399189249_Monitoring_rynka_psihoaktivnoj_produkcii_Analiz_tendencij_Vypusk_72_Dekabr_2025_azyk_-_russkij</ref>

[[File:Alpravalzafone without regards to geometry.svg|thumb|alt=Chemical structure of Alpravalzafone (Without regards to geometry)|Chemical structure of Alpravalzafone (Without regards to geometry)]]

It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone. Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam.<ref>Posted on Reddit by user u/Capable_Sugar_5806 on 14th of April 2026: https://old.reddit.com/r/researchchemicals_DE/comments/1sl9nwr/alpravalzafone_positiver_laborbefund_auf_mehrere/</ref> It is hereby unclear why the report includes the metabolite Oxazepam, as Alpravalzafone cannot metabolize into Oxazepam under normal conditions due to the addition of a triazolo group (the pentyl ring containing three nitrogens at the very top of the molecule), so contamination by the vendor or cross-contamination from other drugs may be possible here.

It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure. The compound was described in scientific literature by Aipsin (A Russian anti-narcotics company) as early as March of 2026, turning up in the first RC Vendor's stores shortly thereafter.

=== Dosage ===
The exact active dose is unclear, however, assuming full metabolism of the prodrug in the bloodstream, comparing the molecular weights, we can estimate that roughly 64% of the prodrug gets converted to Alprazolam.

Alprazolam's molecular weight: 308.77 g/mol
Alpravalzafone's molecular weight: 482.38g/mol

Therefore:
308.77/482.38 = 0.6400970189 ~ 64%

It is unclear what exactly the redundant metabolites of this prodrug are, so currently use is not advised.

=== Chemistry ===

'''Basic data:'''
Formula: C22H25Cl2N5O2
Molar mass: 462.38g/mol
SMILES: NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C
Systemic IUPAC name: 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid

'''Solubility:'''
According to a user on eve&rave.ch, the powdered version of Alpravalzafone is very soluble in a 37,5% ethanol in water solution. Please note that co-ingestion of benzodiazepines with larger amounts of ethanol may posses additional dangers.<ref>Posted on 21. February 2026 by user pincone on eve&rave: https://forum.eve-rave.ch/viewtopic.php?t=83423</ref>

In a test performed by the editor, Alpravalzafone completely dissolved in both descaled tap water as well as a 99,9% pure propylene glycol solution.

=== Legal status ===
Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however, would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and hydrolizes back into the closed ring form.

Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. Full text available at: https://aipsin.com/newsubstance/1931/</ref>

=== Sources ===
<references />

Substance:Alpravalzafone

2026-05-11T10:22:09Z

Skali: Add molecular structure

File:Alpravalzafone without regards to geometry.svg

2026-05-11T10:19:20Z

Skali:

The chemical structure of alpravalzafone without regards to exact geometry of the molecule.

Substance:Alpravalzafone

2026-05-11T10:18:14Z

Skali:

Substance:Alpravalzafone

2026-05-11T10:17:43Z

Skali: Initial pull