Substance:Alpravalzafone - Revision history

Xenorio at 15:55, 12 May 2026

2026-05-12T15:55:21Z

← Older revision		Revision as of 15:55, 12 May 2026
Line 9:		Line 9:
	\| iupac = 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid		\| iupac = 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid
	\| smiles = NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C		\| smiles = NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C
	~~\| legal_de = Not scheduled (NpSG grey area)~~
	~~\| legal_ru = Not scheduled~~
	~~\| legal_by = Not scheduled~~
	}}		}}

Xenorio at 15:36, 12 May 2026

2026-05-12T15:36:07Z

← Older revision		Revision as of 15:36, 12 May 2026
Line 39:		Line 39:

	{{#invoke:LegalStatus\|render		{{#invoke:LegalStatus\|render
	\| de = grey \| de_note = NpSG grey area — unscheduled in open-ring (prodrug) form, but would fall under NpSG restrictions upon hydrolysis to closed-ring form		\| de = grey
	\| ru = unscheduled \| ru_note = Not listed as controlled; confirmed by Аипсин<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. https://aipsin.com/newsubstance/1931/</ref>		\| de_note = NpSG grey area — unscheduled in open-ring (prodrug) form, but would fall under NpSG restrictions upon hydrolysis to closed-ring form
			\| ru = unscheduled
			\| ru_note = Not listed as controlled; confirmed by Аипсин<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. https://aipsin.com/newsubstance/1931/</ref>
	\| by = unscheduled		\| by = unscheduled
	}}		}}

Xenorio at 15:25, 12 May 2026

2026-05-12T15:25:23Z

← Older revision		Revision as of 15:25, 12 May 2026
Line 38:		Line 38:
	=== Legal status ===		=== Legal status ===

	{{~~Legal status}}~~		{{#invoke:LegalStatus\|render
	~~{{Legal status/row\|🇩🇪 Germany~~\|grey\|NpSG grey area — unscheduled in open-ring (prodrug) form, but would fall under NpSG restrictions upon hydrolysis to closed-ring form}}		\| de = grey \| de_note = NpSG grey area — unscheduled in open-ring (prodrug) form, but would fall under NpSG restrictions upon hydrolysis to closed-ring form
	~~{{Legal status/row\|🇷🇺 Russia~~\|unscheduled\|Not listed as controlled; confirmed by Аипсин<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. https://aipsin.com/newsubstance/1931/</ref>}}		\| ru = unscheduled \| ru_note = Not listed as controlled; confirmed by Аипсин<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. https://aipsin.com/newsubstance/1931/</ref>
	~~{{Legal status/row\|🇧🇾 Belarus~~\|unscheduled}}		\| by = unscheduled
	~~{{Legal status/end~~}}		}}

	=== Sources ===		=== Sources ===

Xenorio at 14:46, 12 May 2026

2026-05-12T14:46:23Z

← Older revision		Revision as of 14:46, 12 May 2026
Line 38:		Line 38:
	=== Legal status ===		=== Legal status ===

	~~Alpravalzafone is as of early May 2026 not a controlled substance~~ in ~~Germany~~, ~~however it~~ would fall under ~~the~~ restrictions ~~imposed by the NpSG as soon as it enters non~~-~~acidic conditions and hydrolyzes back into the closed~~ ring form.		{{Legal status}}
			{{Legal status/row\|🇩🇪 Germany\|grey\|NpSG grey area — unscheduled in open-ring (prodrug) form, but would fall under NpSG restrictions upon hydrolysis to closed-ring form}}
	~~Alpravalzafone is not currently considered a~~ controlled ~~substance in Russia or Belarus.~~<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. ~~Full text available at:~~ https://aipsin.com/newsubstance/1931/</ref>		{{Legal status/row\|🇷🇺 Russia\|unscheduled\|Not listed as controlled; confirmed by Аипсин<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. https://aipsin.com/newsubstance/1931/</ref>}}
			{{Legal status/row\|🇧🇾 Belarus\|unscheduled}}
			{{Legal status/end}}

	=== Sources ===		=== Sources ===

Xenorio at 14:23, 12 May 2026

2026-05-12T14:23:39Z

← Older revision		Revision as of 14:23, 12 May 2026
Line 1:		Line 1:
	Alpravalzafone ~~is a water-soluble prodrug of what is currently~~ to ~~be assumed~~ Alprazolam.<~~ref~~>~~Yurchenko~~, ~~Ruslan; Vydra~~, ~~Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya~~ (~~31 March 2026~~)~~. "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026.~~ (~~язык - русский~~)~~". АИПСИН~~ (75)~~: 5. doi:10.13140/RG.2.2.20692.36486.~~		{{Substance
			\| name = Alpravalzafone
			\| image = Alpravalzafone without regards to geometry.svg
			\| image_caption = Chemical structure (without regards to geometry)
			\| class = Benzodiazepine
			\| prodrug_of = Alprazolam
			\| formula = C<sub>22</sub>H<sub>25</sub>Cl<sub>2</sub>N<sub>5</sub>O<sub>2</sub>
			\| molar_mass = 482.38
			\| iupac = 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid
			\| smiles = NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C
			\| legal_de = Not scheduled (NpSG grey area)
			\| legal_ru = Not scheduled
			\| legal_by = Not scheduled
			}}

	Full text available here: https://www.researchgate.net/publication/399189249_Monitoring_rynka_psihoaktivnoj_produkcii_Analiz_tendencij_Vypusk_72_Dekabr_2025_azyk_-_russkij</ref>		Alpravalzafone is a water-soluble prodrug of what is currently assumed to be [[Substance:Alprazolam\|Alprazolam]].<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486. Full text available here: https://www.researchgate.net/publication/399189249_Monitoring_rynka_psihoaktivnoj_produkcii_Analiz_tendencij_Vypusk_72_Dekabr_2025_azyk_-_russkij</ref>

	~~[[File:Alpravalzafone without regards~~ to ~~geometry~~.~~svg\|thumb\|alt=Chemical structure~~ of Alpravalzafone ~~(Without regards~~ to ~~geometry)\|Chemical structure~~ of ~~Alpravalzafone~~ (~~Without regards to geometry~~)]]		It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone. Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam.<ref>Posted on Reddit by user u/Capable_Sugar_5806 on 14 April 2026: https://old.reddit.com/r/researchchemicals_DE/comments/1sl9nwr/alpravalzafone_positiver_laborbefund_auf_mehrere/</ref> It is hereby unclear why the report includes the metabolite Oxazepam, as Alpravalzafone cannot metabolize into Oxazepam under normal conditions due to the addition of a triazolo group (the pentyl ring containing three nitrogens at the top of the molecule), so contamination by the vendor or cross-contamination from other drugs may be possible here.

	It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone. Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam.<ref>Posted on Reddit by user u/Capable_Sugar_5806 on 14th of April 2026: https://old.reddit.com/r/researchchemicals_DE/comments/1sl9nwr/alpravalzafone_positiver_laborbefund_auf_mehrere/</ref> It is hereby unclear why the report includes the metabolite Oxazepam, as Alpravalzafone cannot metabolize into Oxazepam under normal conditions due to the addition of a triazolo group (the pentyl ring containing three nitrogens at the very top of the molecule), so contamination by the vendor or cross-contamination from other drugs may be possible here.		It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure. The compound was described in scientific literature by Aipsin (a Russian anti-narcotics company) as early as March 2026, turning up in the first RC vendor stores shortly thereafter.

	It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure. The compound was described in scientific literature by Aipsin (A Russian anti-narcotics company) as early as March of 2026, turning up in the first RC ~~Vendor's~~ stores shortly thereafter.

	=== Dosage ===		=== Dosage ===
	The exact active dose is unclear, however, assuming full metabolism of the prodrug in the bloodstream, comparing the molecular weights, we can estimate that roughly 64% of the prodrug gets converted to Alprazolam.

	~~Alprazolam's molecular weight: 308.77 g/mol~~

	~~Alpravalzafone's~~ molecular ~~weight~~: ~~482.38g/mol~~		The exact active dose is unclear. Assuming full metabolism of the prodrug in the bloodstream, the conversion ratio to Alprazolam can be estimated by comparing molecular weights:

	~~Therefore:~~		<math>\frac{M_{\text{Alprazolam}}}{M_{\text{Alpravalzafone}}} = \frac{308.77}{482.38} \approx 64\%</math>
	308.77/482.38 ~~= 0.6400970189 ~~~ 64%

	It is unclear what ~~exactly~~ the redundant metabolites of this prodrug are, so ~~currently~~ use is not advised. It is likely this prodrug releases either isoleucineamide or isoleucine, as there are only five carbon atoms required to close the diazepine ring. No reliable reports on the metabolism of this prodrug have yet been encountered.		It is unclear what the redundant metabolites of this prodrug are, so use is not currently advised. It is likely this prodrug releases either isoleucineamide or isoleucine, as there are only five carbon atoms required to close the diazepine ring. No reliable reports on the metabolism of this prodrug have yet been encountered.

	=== Chemistry ===		=== Chemistry ===

	~~'''Basic data:'''~~

	~~Formula: C<sub>22</sub>H<sub>25</sub>Cl<sub>2</sub>N<sub>5</sub>O<sub>2</sub>~~

	~~Molar mass: 462.38g/mol~~

	~~SMILES: NC(C(=O)NCC1=NN=C(N1C1=C(C=C(C=C1)Cl)C(C1=CC=CC=C1)=O)C)C(C)C~~

	~~Systemic IUPAC name: 2-amino-N-((4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)-3-methylbutanamid~~

	'''Solubility:'''		'''Solubility:'''

	According to a user on eve&rave.ch, the powdered version of Alpravalzafone is very soluble in a 37,5% ethanol in water solution. ~~Please note~~ that co-ingestion of benzodiazepines with larger amounts of ethanol may ~~posses~~ additional dangers.<ref>Posted on 21. February 2026 by user pincone on eve&rave: https://forum.eve-rave.ch/viewtopic.php?t=83423</ref>		According to a user on eve&rave.ch, the powdered version of Alpravalzafone is very soluble in a 37.5% ethanol in water solution. Note that co-ingestion of benzodiazepines with larger amounts of ethanol may pose additional dangers.<ref>Posted on 21 February 2026 by user pincone on eve&rave: https://forum.eve-rave.ch/viewtopic.php?t=83423</ref>

	In a test performed by the editor, Alpravalzafone hydrochloride completely dissolved in both descaled tap water ~~as well as~~ a 99,9% pure propylene glycol solution.		In a test performed by the editor, Alpravalzafone hydrochloride completely dissolved in both descaled tap water and a 99.9% pure propylene glycol solution.

	=== Legal status ===		=== Legal status ===
	Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however, would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and ~~hydrolizes~~ back into the closed ring form.
			Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however it would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and hydrolyzes back into the closed ring form.

	Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. Full text available at: https://aipsin.com/newsubstance/1931/</ref>		Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.<ref>"Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026. Full text available at: https://aipsin.com/newsubstance/1931/</ref>

Xenorio: Xenorio moved page Wiki/Alpravalzafone to Substance:Alpravalzafone

2026-05-12T12:56:46Z

Xenorio moved page Wiki/Alpravalzafone to Substance:Alpravalzafone

← Older revision		Revision as of 12:56, 12 May 2026
(No difference)

Skali at 13:40, 11 May 2026

2026-05-11T13:40:57Z

← Older revision		Revision as of 13:40, 11 May 2026
Line 1:		Line 1:
	~~DISPLAYTITLE~~

	Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.		Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Skali at 13:40, 11 May 2026

2026-05-11T13:40:45Z

← Older revision		Revision as of 13:40, 11 May 2026
Line 1:		Line 1:
			DISPLAYTITLE

	Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.		Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Line 50:		Line 52:
	[[Category:Research chemicals]]		[[Category:Research chemicals]]
	[[Category:Substances]]		[[Category:Substances]]
			__INDEX__

Skali at 13:40, 11 May 2026

2026-05-11T13:40:23Z

← Older revision		Revision as of 13:40, 11 May 2026
Line 1:		Line 1:
	~~DISPLAYTITLE~~

	Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.		Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.

Skali: Added categories, made page title more appealing

2026-05-11T13:40:11Z

Added categories, made page title more appealing

@@ Line 1: / Line 1: @@
 Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.<ref>Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.
@@ Line 46: / Line 48: @@
 === Sources ===
 <references />